Periayah MH, Halim AS, Mat Saad AZ, et al.
International journal of hematology-oncology and stem cell research. Date of publication 2017 Oct 1;volume 11(4):319-327.
1. Int J Hematol Oncol Stem Cell Res. 2017 Oct 1;11(4):319-327.
Mechanism Action of Platelets and Crucial Blood Coagulation Pathways in
Hemostasis.
Periayah MH(1), Halim AS(1), Mat Saad AZ(1).
Author information:
(1)Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains
Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Blood is considered to be precious because it is the basic necessity for health;
our body needs a steady provision of oxygen, supplied via blood, to reach
billions of tissues and cells. Hematopoiesis is the process that generates blood
cells of all lineages. However, platelets are the smallest blood component
produced from the very large bone marrow cells called megakaryocytes and they
play a fundamental role in thrombosis and hemostasis. Platelets contribute their
hemostatic capacity via adhesion, activation and aggregation, which are triggered
upon tissue injury, and these actions stimulate the coagulation factors and other
mediators to achieve hemostasis. In addition, these coordinated series of events
are the vital biological processes for wound healing phases. The aim of this
review is to summarize and highlight the important pathways involved in achieving
hemostasis that are ruled by platelets. In addition, this review also describes
the mechanism action of platelets, including adhesion, activation, aggregation,
and coagulation, as well as the factors that aid in hemostasis and wound healing.
PMCID: PMC5767294
PMID: 29340130
