Schottlender N, Gottfried I, Ashery U, et al.
Biomolecules. Date of publication 2021 Dec 3;volume 11(12):.
1. Biomolecules. 2021 Dec 3;11(12):1827. doi: 10.3390/biom11121827.
Hyperbaric Oxygen Treatment: Effects on Mitochondrial Function and Oxidative
Stress.
Schottlender N(1)(2), Gottfried I(1), Ashery U(1)(2).
Author information:
(1)School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty,
Tel Aviv University, Tel Aviv 69978, Israel.
(2)Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel.
Hyperbaric oxygen treatment (HBOT)-the administration of 100% oxygen at
atmospheric pressure (ATA) greater than 1 ATA-increases the proportion of
dissolved oxygen in the blood five- to twenty-fold. This increase in accessible
oxygen places the mitochondrion-the organelle that consumes most of the oxygen
that we breathe-at the epicenter of HBOT's effects. As the mitochondrion is also
a major site for the production of reactive oxygen species (ROS), it is possible
that HBOT will increase also oxidative stress. Depending on the conditions of
the HBO treatment (duration, pressure, umber of treatments), short-term
treatments have been shown to have deleterious effects on both mitochondrial
activity and production of ROS. Long-term treatment, on the other hand, improves
mitochondrial activity and leads to a decrease in ROS levels, partially due to
the effects of HBOT, which increases antioxidant defense mechanisms. Many
diseases and conditions are characterized by mitochondrial dysfunction and
imbalance between ROS and antioxidant scavengers, suggesting potential
therapeutic intervention for HBOT. In the present review, we will present
current views on the effects of HBOT on mitochondrial function and oxidative
stress, the interplay between them and the implications for several diseases.
DOI: 10.3390/biom11121827
PMCID: PMC8699286
PMID: 34944468 [Indexed for MEDLINE]
Conflict of interest statement: The authors declare no conflict of interest.
