Tannenbaum R, Strunk A, Garg A, et al.
Journal of the American Academy of Dermatology. Date of publication 2019 Feb 7;volume ():.
1. J Am Acad Dermatol. 2019 Feb 7. pii: S0190-9622(19)30200-2. doi:
10.1016/j.jaad.2019.02.004. [Epub ahead of print]
Overall and subgroup prevalence of pyoderma gangrenosum among patients with
hidradenitis suppurativa: A population-based analysis in the United States.
Tannenbaum R(1), Strunk A(1), Garg A(2).
Author information:
(1)Department of Dermatology, Donald and Barbara Zucker School of Medicine at
Hofstra Northwell, New Hyde Park, New York.
(2)Department of Dermatology, Donald and Barbara Zucker School of Medicine at
Hofstra Northwell, New Hyde Park, New York. Electronic address:
amgarg@northwell.edu.
BACKGROUND: Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are
reported to coexist, although the prevalence of PG among patients with HS has not
been systematically evaluated.
OBJECTIVE: To evaluate PG prevalence among patients with HS.
METHODS: Cross-sectional analysis of adults with PG among patients with HS and
patients without HS through use of electronic health records data from a
population-based sample of 55 million patients.
RESULTS: The prevalence of PG among 68,232 patients with HS was 0.18% (125 of
68,232), compared with 0.01% (1835 of 31,435,166) among those without HS
(P < .0001). Prevalence was markedly higher among patients with HS and Crohn's
disease (CD) (3.68%) than among patients with HS but without CD (0.12%). The odds
of having PG were 21.14 (95% confidence interval [CI], 17.51-25.51) times greater
among patients with HS than among those without HS. Patients with HS with CD had
12.38 (95% CI, 9.15-16.74) times the odds of having PG than did patients without
HS but with CD. Among patients without CD, compared with patients without HS,
those with HS had 26.51 (95% CI, 21.07-33.36) times the odds of having PG.
LIMITATIONS: We could not establish HS phenotype among those having coexistent
PG, nor could we distinguish syndromic from nonsyndromic cases.
CONCLUSION: Patients with HS have an increased prevalence of PG, regardless of CD
status. Painful ulcerations among patients with HS warrant additional evaluation
for PG.
Copyright © 2019 American Academy of Dermatology, Inc. Published by Elsevier Inc.
All rights reserved.
DOI: 10.1016/j.jaad.2019.02.004
PMID: 30738122
