Jenwitheesuk K, Mahakkanukrauh A, Punjaruk W, Jenwitheesuk K, Chowchuen B, Jinaporntham S, Uraiwan K, Limrattanapimpa P, et al.
BioResearch open access. Date of publication 2018 Oct 8;volume 7(1):145-149.
1. Biores Open Access. 2018 Oct 8;7(1):145-149. doi: 10.1089/biores.2018.0019.
eCollection 2018.
Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis.
Jenwitheesuk K(1), Mahakkanukrauh A(2), Punjaruk W(3), Jenwitheesuk K(4)(5),
Chowchuen B(1), Jinaporntham S(6), Uraiwan K(7), Limrattanapimpa P(8).
Author information:
(1)Plastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of
Medicine, Khon Kaen University, Khon Kaen, Thailand.
(2)Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty
of Medicine, Khon Kaen University, Khon Kaen, Thailand.
(3)Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon
Kaen, Thailand.
(4)General Surgery Unit, Department of Surgery, Faculty of Medicine, Khon Kaen
University, Khon Kaen, Thailand.
(5)Sleep Apnea Research Group, Research Center in Back, Neck and Other Joint Pain
and Human Performance, Khon Kaen University, Khon Kaen, Thailand.
(6)Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Khon Kaen
University, Khon Kaen, Thailand.
(7)Department of Dental, Srinagarind Hospital, Faculty of Medicine, Khon Kaen
University, Khon Kaen, Thailand.
(8)Hospital Hyperbaric Oxygen Therapy Unit, Srinagarind Hospital, Faculty of
Medicine, Khon Kaen University, Khon Kaen, Thailand.
Osteoradionecrosis (ORN) is a common consequence resulting from radiation in
patients with cancer. Presently, hyperbaric oxygen therapy (HBOT) is proposed to
have a role in improving wound healing in ORN patients. There is no strong
scientific evidence to confirm the benefits of HBOT for treatment of ORN as an
adjunctive treatment. This study aimed to determine the benefits of adjunctive
treatment of HBOT in ORN. A retrospective study was conducted at the Srinagarind
Hospital, the Faculty of Medicine, Khon Kaen University, Thailand, between 2011
and 2017. The patients diagnosed with ORN, who received adjunctive HBOT before
the operation, were enrolled. Complete healing of wounds was the primary outcome.
There were 84 ORN patients with a mean age of 58.78 years; 54.76% were male and
45.24% were female. HBOT had a role significant in improving wound healing of ORN
patients with stages 1 and 2. Poisson regression analysis showed that stage 3 of
ORN negatively correlated with the number of HBOT dives (p = 0.001, incidence
rates ratio = 0.85). In conclusion, HBOT improved wound healing of ORN patients
with stages 1 and 2. In addition, stage 2 of ORN patients significantly required
the highest number of HBOT dives compared to other types of ORN to promote wound
healing, whereas stage 3 patients, who underwent bone debridement combined with
HBOT, initiated to success of treatment process and required a smaller number of
dives.
DOI: 10.1089/biores.2018.0019
PMCID: PMC6178923
PMID: 30310729
Conflict of interest statement: No competing financial interests exist.
