Lagus H, Sarlomo-Rikala M, Böhling T, Vuola J, et al.
Burns : journal of the International Society for Burn Injuries. Date of publication 2013 Dec 1;volume 39(8):1577-87.
1. Burns. 2013 Dec;39(8):1577-87. doi: 10.1016/j.burns.2013.04.023. Epub 2013 Jul
20.
Prospective study on burns treated with Integra®, a cellulose sponge and split
thickness skin graft: comparative clinical and histological study--randomized
controlled trial.
Lagus H(1), Sarlomo-Rikala M, Böhling T, Vuola J.
Author information:
(1)Department of Surgery, Hyvinkää Hospital, Hyvinkää, Finland. Electronic
address: heli.lagus@hus.fi.
BACKGROUND: The aim of this study was to compare three different methods to cover
excised burn wounds in a randomized controlled trial.
METHODS: Fascially excised burn wounds, measuring 10 cm × 5 cm, were covered with
Integra(®), split thickness skin graft (STSG), and a viscose cellulose sponge
Cellonex™ in each of ten adult patients. Integra(®) and Cellonex™ treated areas
were covered with thin STSG on day 14. Biopsies were taken 3, 7, 14, and 21 days,
3 months, and 12 months after surgery, and samples were subjected to a range of
immunohistochemical stains, in addition to hematoxylin and eosin (HE). Scar
assessment was performed 3 and 12 months post-operatively with the Vancouver Scar
Scale (VSS).
RESULTS: Inflammation was not substantial in any of the study areas, but
Cellonex™ had the most neutrophils, histiocytes, and lymphocytes with significant
differences on days 7 and 14. Complete vascularization of Integra(®) seemed to
occur later compared to the other materials. STSG had the most myofibroblasts on
day 14 (p = 0.012). In VSS the quality of the scar improved in all materials from
3 to 12 months.
CONCLUSIONS: The final results for all treatments after 12 months demonstrate
equal clinical appearance, as well as histological and immunohistochemical
findings.
Copyright © 2013 Elsevier Ltd and ISBI. All rights reserved.
DOI: 10.1016/j.burns.2013.04.023
PMID: 23880091 [Indexed for MEDLINE]
