Kloeters O, Unglaub F, de Laat E, van Abeelen M, Ulrich D, et al.
International wound journal. Date of publication 2016 Dec 1;volume 13(6):1231-1236.
1. Int Wound J. 2016 Dec;13(6):1231-1236. doi: 10.1111/iwj.12449. Epub 2015 May 23.
Prospective and randomised evaluation of the protease-modulating effect of
oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers.
Kloeters O(1), Unglaub F(2), de Laat E(1), van Abeelen M(1), Ulrich D(1).
Author information:
(1)Department of Plastic and Reconstructive Surgery, Radboud University Hospital,
Nijmegen, The Netherlands.
(2)Department of Handsurgery, Vulpius Klinik, Bad Rappenau, Germany.
In chronic wounds, excess levels and activity of proteases such as elastase and
plasmin have been detected. Oxidised regenerated cellulose/collagen matrix
(ORC/collagen matrix) has been reported to ameliorate the wound microenvironment
by binding and inactivating excess proteases in wound exudates. In this study,
the levels and activity of elastase and plasmin in wound exudates of pressure
sore ulcers were measured to determine the beneficial effect of ORC/collagen
matrix treatment compared with control treatment with a foam dressing. A total of
33 patients with pressure sores were enrolled in the study and were followed up
for 12 weeks after treatment. Ten control patients were treated with a foam
hydropolymer dressing (TIELLE® , Systagenix), and the remaining 23 patients were
treated with ORC/collagen matrix plus the foam dressing (TIELLE® , Systagenix) on
top. Wound assessments were carried out over 12 weeks on a weekly basis, with
dressing changes twice a week. Ulcers were photographed and wound exudates were
collected on admission and at days 5, 14 and then every 14 days to provide a
visual record of any changes in appearance of the ulcer and healing rate and for
biochemical analysis of the wound. The levels and activity of elastase and
plasmin were measured in wound exudates. Statistical analysis was performed using
ANOVA and Bonferroni's post hoc test with P-values <0·05 considered to be
significant. Compared with controls, ORC/collagen matrix-treated pressure sore
wounds showed a significant faster healing rate, which positively correlated with
a decreased activity of elastase and plasmin in wound exudates. No signs of
infection or intolerance to the ORC/collagen matrix were observed.
© 2015 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
DOI: 10.1111/iwj.12449
PMID: 26011241 [Indexed for MEDLINE]
