Arsenault KA, McDonald J, Devereaux PJ, Thorlund K, Tittley JG, Whitlock RP, et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the Eur.... Date of publication 2011 Nov 1;volume 19(6):657-63.
1. Wound Repair Regen. 2011 Nov;19(6):657-63. doi: 10.1111/j.1524-475X.2011.00731.x.
Epub 2011 Oct 10.
The use of transcutaneous oximetry to predict complications of chronic wound
healing: a systematic review and meta-analysis.
Arsenault KA(1), McDonald J, Devereaux PJ, Thorlund K, Tittley JG, Whitlock RP.
Author information:
(1)Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Transcutaneous oximetry (P(tc) O(2) ) has been proposed as a method to predict
nonhealing of chronic wounds and the occurrence of healing complications.
However, the validity of this method as an independent predictor and an optimal
threshold value for this tool are poorly defined. We undertook a systematic
review and meta-analysis to address these questions, searching five major medical
databases, relevant review articles, and reference lists. We included all studies
that used multivariable analysis to evaluate P(tc) O(2) for its ability to
predict chronic wound healing complications. Article selection and data
abstraction were conducted independently and in duplicate. Four studies,
enrolling 901 patients with 910 lower extremity chronic wounds, met our inclusion
criteria. These studies showed that a peri-wound P(tc) O(2) level below a cutoff
of 20 mmHg or 30 mmHg was an independent predictor of chronic wound healing
complications (odds ratio 3.21, 95% confidence interval 1.07-9.69, I(2) = 77%).
A threshold value of 20 mmHg was used most frequently in the included studies and
showed the strongest association. This review was limited by the small number of
studies, a possible reporting bias, and heterogeneity. These results suggest that
P(tc) O(2) measurements have independent prognostic value in the assessment of
chronic wounds, but further research is required to confirm these findings and
define an optimal threshold value.
2011 by the Wound Healing Society.
DOI: 10.1111/j.1524-475X.2011.00731.x
PMID: 22092835 [Indexed for MEDLINE]
