Doctrow SR, Lopez A, Schock AM, Duncan NE, Jourdan MM, Olasz EB, Moulder JE, Fish BL, Mäder M, Lazar J, Lazarova Z, et al.
The Journal of investigative dermatology. Date of publication 2013 Apr 1;volume 133(4):1088-96.
1. J Invest Dermatol. 2013 Apr;133(4):1088-96. doi: 10.1038/jid.2012.410. Epub 2012
Nov 29.
A synthetic superoxide dismutase/catalase mimetic EUK-207 mitigates radiation
dermatitis and promotes wound healing in irradiated rat skin.
Doctrow SR(1), Lopez A, Schock AM, Duncan NE, Jourdan MM, Olasz EB, Moulder JE,
Fish BL, Mäder M, Lazar J, Lazarova Z.
Author information:
(1)Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
Erratum in
J Invest Dermatol. 2013 Jun;133(6):1691.
In the event of a radionuclear attack or nuclear accident, the skin would be the
first barrier exposed to radiation, though skin injury can progress over days to
years following exposure. Chronic oxidative stress has been implicated as being a
potential contributor to the progression of delayed radiation-induced injury to
skin and other organs. To examine the causative role of oxidative stress in
delayed radiation-induced skin injury, including impaired wound healing, we
tested a synthetic superoxide dismutase (SOD)/catalase mimetic, EUK-207, in a rat
model of combined skin irradiation and wound injury. Administered systemically,
beginning 48 hours after irradiation, EUK-207 mitigated radiation dermatitis,
suppressed indicators of tissue oxidative stress, and enhanced wound healing.
Evaluation of gene expression in irradiated skin at 30 days after exposure
revealed a significant upregulation of several key genes involved in detoxication
of reactive oxygen and nitrogen species. This gene expression pattern was
primarily reversed by EUK-207 therapy. These results demonstrate that oxidative
stress has a critical role in the progression of radiation-induced skin injury,
and that the injury can be mitigated by appropriate antioxidant compounds
administered 48 hours after exposure.
DOI: 10.1038/jid.2012.410
PMCID: PMC3594042
PMID: 23190879 [Indexed for MEDLINE]
