Haruna F, Lipsett A, Marignol L, et al.
Anticancer research. Date of publication 2017 Oct 1;volume 37(10):5343-5353.
1. Anticancer Res. 2017 Oct;37(10):5343-5353.
Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A
Systematic Review and Meta-Analysis.
Haruna F(1), Lipsett A(1), Marignol L(2).
Author information:
(1)Applied Radiation Therapy Trinity (ARTT), Discipline of Radiation Therapy,
School of Medicine, Trinity College Dublin, Dublin, Ireland.
(2)Applied Radiation Therapy Trinity (ARTT), Discipline of Radiation Therapy,
School of Medicine, Trinity College Dublin, Dublin, Ireland marignol@tcd.ie.
AIM: To evaluate the efficacy of topical corticosteroids in managing acute
radiation dermatitis (RD) in female breast cancer patients.
MATERIALS AND METHODS: MEDLINE, EMBASE, CINAHL, CENTRAL, ScienceDirect, Google
Scholar and Clinicaltrials.gov were searched up to and including March 2017 to
identify Randomised Controlled Trials (RCTs) assessing topical corticosteroids
for the management and prevention of acute RD.
RESULTS: Ten RCTs (919 participants) were identified. Meta-analysis, including
results for 845 participants, demonstrated significant benefits of topical
corticosteroids in preventing the incidence of wet desquamation (OR: 0.29; 95%CI:
0.19-0.45; p<0.0001) and reducing the mean RD score (SMD: -0.47, 95%CI: -0.61 -
-0.33, p<0.00001).
CONCLUSION: Topical corticosteroids impacted on the incidence of wet desquamation
and the average RD score observed in female breast cancer patients. The use of
topical corticosteroids can reduce pruritus in participants and improve quality
of life.
Copyright© 2017, International Institute of Anticancer Research (Dr. George J.
Delinasios), All rights reserved.
DOI: 10.21873/anticanres.11960
PMID: 28982842 [Indexed for MEDLINE]
