Lisa,
Thanks for your question. Per our conversation, the patient had a total of 5,440 cGy in 17 fractions following the excision of a lower extremity squamous cell carcinoma, resulting in a wound that has been present for 72 weeks.
Delayed radiation complications often manifest as non-healing wounds in previously irradiated areas. The wounds can be precipitated by an external insult such as surgery, trauma, or even minor trauma. Some of these wounds are visible, and some are not (e.g., radiation cystitis, vaginitis, proctitis, and urethritis). Hyperbaric oxygen has been shown to induce neovascularization and increase cellularity in irradiated and other hypoxic tissues.
Regarding criteria or qualification as a candidate for HBOT for Soft Tissue Radiation Necrosis:
- Non-healing wound within a previously irradiated area with at least six months since last radiation exposure
- History of radiation treatment (usually in excess of 40 Gray or 4,000 cGy) to the region of the documented injury
- Wound that is non-responsive to conservative standard treatment.
Also, documentation of a comprehensive history and physical exam should include the following details: The date of cancer diagnosis, the date when radionecrosis was diagnosed, the specific type of radiation source used, the total dosage administered over the entire course of treatments, the radiation fraction applied (for example, "Thirty sessions of electron beam radiation targeting the prostate gland, with each session delivering 200 cGy fractions, resulting in a cumulative total of 6,000 cGy"), the span of dates during which radiation was administered, and any preceding treatments or therapies.
Again, thanks for your question. Please let us know if you have any additional thoughts or questions.
Have a great day! Jeff